Professor Małgorzata Filip’s research focuses on the mechanisms underlying brain function in physiological and pathological conditions, using network neuroscience approaches. She investigates behavioural phenotypes by recording in vivo and ex vivo activity across multiple levels of brain organization, including protein interactions, genetic and epigenetic networks, synaptic connections, and system-level communication influenced by environmental factors such as stress, drugs of abuse, and diet.
She specializes in preclinical models of substance use disorders, depression, anxiety, and neurodevelopmental disorders. Her team has elucidated key signalling pathways in the rat brain associated with substance abuse. In collaboration with international partners, she demonstrated the role of heteroreceptor complexes and novel treatment strategies in cocaine use disorder. Her group introduced a new pharmacological concept based on NMDA receptor–scaffolding protein interactions and showed anti-craving effects of N-acetylcysteine amide (US patent). Her recent work has identified maternal feeding programs as potent triggers of behavioural and molecular phenotypes in offspring.
Prof. Filip’s research is funded by national and international agencies. She has also served as an ERC panel member. She has received numerous research awards and state honours, and is a member of the Polish Academy of Arts and Sciences and the Polish Academy of Sciences.